2021 Annual Meeting Knee Access Pass-The beneficial effect of intra-articular injection of losartan on the microfracture mediated cartilage repair is dose dependent

The beneficial effect of intra-articular injection of losartan on the microfracture mediated cartilage repair is dose dependent

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Video Transcription

Video Summary

In this video, the speaker discusses the use of lisartan for cartilage healing. They mention that oral intake of lisartan has shown positive results in animal models for cartilage healing compared to microfracture alone. However, the effects of locally injected lisartan in the normal joint are unknown. The speaker references several studies conducted by Dr. Johnny Heward, highlighting the blocking of TGF-beta by lisartan resulting in improved healing. They also mention lisartan's FDA-approved use for hypertension and its off-label use for prevention of adhesion formation in hip arthroscopy. The speaker presents their own study on the intraarticular injection of lisartan in rabbits and finds that low doses improve articular cartilage healing while high doses are detrimental. They note the study's limitations and emphasize the need for further investigation before implementing it clinically. The speaker acknowledges the assistance of multiple scientists in conducting the study.

Asset Caption

Dr. Catherine Logan

Meta Tag

Concept Losartan

Concept Microfracture

Concept Cartilage Repair

Concept Transforming Growth Factor Beta

Concept Dose-Response Effect

Keywords

lisartan

cartilage healing

TGF-beta blocking

animal models

intraarticular injection

Losartan

Microfracture

Cartilage Repair

Transforming Growth Factor Beta

Dose-Response Effect