2021 Annual Meeting Startup & Practice Management Access Pass-Mechano-Activated Drug Delivery of Growth Factors as a Novel Platform for Enhancing Cartilage Regeneration

Mechano-Activated Drug Delivery of Growth Factors as a Novel Platform for Enhancing Cartilage Regeneration

Video Transcription

Video Summary

The video transcript is a presentation of a proposal for an ex vivo experimental model using a unique drug delivery system called mechanoactivated microcapsules (MAMCs) to enhance cartilage integration and regeneration. The proposal is a partnership between the University of Pennsylvania and a spinout company called McKenna Therapeutics. The development of novel cartilage restoration procedures has advanced the field of cartilage repair, but integrating the repaired cartilage remains a challenge. The aim of the proposal is to improve cartilage to cartilage integration and fill in cartilage gaps using MAMCs. These microcapsules are designed to rupture under mechanical force, releasing a therapeutic payload for targeted and controlled delivery to stimulate cartilage regeneration. The proposal plans to evaluate the efficacy of MAMC-released fibroblast growth factor 18 (FGF18) in improving cartilage regeneration and integration strength. The study will use an ex vivo experimental model with bovine cartilage disks and measure repair strength, biochemical and histological analysis. The team includes experts in cartilage biology, orthopedic surgery, sports medicine, mechanobiology, chemical, and mechanical engineering. The proposal aims to revolutionize cartilage regeneration and improve patient outcomes.

Asset Caption

Dr. Nicholas DePhilippo

Keywords

ex vivo experimental model

mechanoactivated microcapsules

cartilage integration

cartilage regeneration

MAMCs