AANA Industry Learning Vault-Moximed Clinical Evidence Webinar: Five-Year Outcomes from the Published CALYPSO Trial

Video Transcription

Video Summary

The webinar introduced MISHA, a dynamic implant for medial knee osteoarthritis that helps unload the stressed medial compartment without replacing the joint. Moderator Neil Ranawat emphasized that it addresses a major treatment gap for patients who are too young, too active, or not yet appropriate for arthroplasty.<br /><br />Speakers Dennis Crawford, Andreas Gaml, and David Deduck reviewed the device’s evolution, clinical background, and five-year results from the Calypso trial. They reported strong outcomes: 96% of patients had clinically meaningful pain relief, 86% had functional improvement, and 90% avoided conversion to arthroplasty or high tibial osteotomy at five years. The implant showed durable mechanical performance with no major hardware failure concerns.<br /><br />The panel discussed ideal patient selection: medial pain, early-to-moderate OA, varus alignment, post-meniscectomy knees, root tears, bone marrow edema, and patients who want to stay active. They stressed that MISHA preserves future surgical options, can be removed safely, and does not require long-term activity restrictions. Several real-world cases showed patients returning to running, tennis, hiking, and active work life.<br /><br />The webinar closed by highlighting training, reimbursement progress, and MISHA’s potential as a game-changing, joint-preserving option.

Asset Caption

Recorded on Wednesday, September 9th, 2026
Faculty: Anil Ranawat, M.D. | Dennis Crawford, M.D., Ph.D. | Andreas Gomoll, M.D. | David Diduch, M.D.

Meta Tag

Concept Internal Shock Absorber

Concept Medial Compartment Knee Osteoarthritis

Concept Dynamic Knee Unloader

Concept Pain Relief

Concept Functional Outcome

Keywords

MISHA

medial knee osteoarthritis

joint-preserving implant

medial compartment unloading

Calypso trial

five-year outcomes

patient selection

varus alignment

arthroplasty avoidance

Internal Shock Absorber

Medial Compartment Knee Osteoarthritis

Dynamic Knee Unloader

Pain Relief

Functional Outcome