AANA19 Knee Access Pass-Preoperative Changes in the Biomarker Profile of the Knee before Anterior Cruciate Ligament (ACL) Reconstruction-Dr. Eric Jason Strauss, M.D.

Preoperative Changes in the Biomarker Profile of the Knee before Anterior Cruciate Ligament (ACL) Reconstruction-Dr. Eric Jason Strauss, M.D.

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Video Transcription

Video Summary

In this video, the speaker discusses the changes in synovial fluid biomarkers in the interval period between ACL injury and surgery. ACL ruptures commonly occur with a pivot shift mechanism, leading to bone marrow edema lesions on MRI. The articular cartilage is exposed to significant loads during the event, releasing cytokines into the joint space. ACL reconstruction is successful, but post-operative recovery and prevention of post-traumatic osteoarthritis are variable. Synovial fluid is an ideal source for potential disease markers due to its availability and higher marker concentrations. The study evaluates the change in biomarker concentrations between the injury and surgery phases. The results show significant differences in eight out of ten biomarkers assessed. The findings suggest that certain markers, like interleukin 6, may indicate the optimal timing for surgical intervention or be potential treatment targets. Limitations of the study include a low sample size and limited time points of collection. The research aims to uncover the role of cytokines in the body's response to injury and their impact on outcomes following ACL reconstruction, potentially leading to personalized management protocols and the prevention of post-traumatic osteoarthritis. The work is supported by the Beaty Family Foundation.

Asset Caption

Concurrent Scientific Session III: Foot and Ankle 5.3.2019

Meta Tag

Concept Pediatric ACL Rupture

Concept Synovial Fluid

Concept Interleukin-6

Concept Inflammation

Concept Cytokine

Keywords

synovial fluid biomarkers

ACL injury

surgery

biomarker concentrations

post-traumatic osteoarthritis

Pediatric ACL Rupture

Synovial Fluid

Interleukin-6

Inflammation

Cytokine