Hype, Promise and Reality: Orthopaedic Use of Biologics in 2024 (2024 Annual Meeting)-Hype, Promise and Reality: Orthopaedic Use of Biologics in 2024

Video Transcription

Video Summary

Platelet-rich plasma (PRP) is discussed in the video for its application in treating tendinopathy and rotator cuff injuries. Studies show varying outcomes, with some positive effects on tendon healing post-rotator cuff repair. Different PRP formulations like leukocyte-rich PRP are recommended for tendinopathy, while other formulations are explored for potential benefits. Precision medicine in biologics is stressed, considering patient responses, cytokine profiles, and dosing accuracy. The complexity of PRP composition, defining biologic targets, and the paracrine mechanism of action in cell-based therapies are also highlighted. Despite outcome variability and the need for more data, PRP shows promise in improving tendon healing. FDA regulations on orthobiologics are discussed, emphasizing the differences between minimally manipulated 361 products and complex 351 products. Healthcare providers are reminded of the importance of understanding regulations to avoid legal issues and to ensure compliance. Staying informed and using reputable resources like the AAOS Orthopedic Biologic website is advised for incorporating cell-based therapies into practice.

Asset Caption

Stephen C. Weber, M.D., Moderator | Scott A. Rodeo, M.D. | Kenneth R. Zaslav, M.D. | Jason L. Dragoo, M.D., FAANA

Keywords

Platelet-rich plasma

PRP

tendinopathy

rotator cuff injuries

tendon healing

precision medicine

biologics

cytokine profiles

dosing accuracy

orthobiologics

FDA regulations