Hype, Promise, and Reality Orthopedic Use of Biologics (2021 Annual Meeting)-Hype, Promise, and Reality: Orthopedic Use of Biologics in 2021'-Dragoo

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Video Summary

The speaker begins by acknowledging that their talk will complement the previous speaker's discussion on regenerative medicine. They mention that the FDA has taken action to remove misleading and misused products from the market in the field of regenerative medicine. The speaker explains that the term "stem cell therapy" has been replaced with "cellular therapy" because the ability of stem cells to create any cell or organ in the body reduces with age. The speaker discusses the therapeutic effects of cellular medicine, including pain relief and anti-inflammatory properties. They also mention emerging evidence suggesting that cellular medicine may be able to regenerate tissues. The speaker then focuses on the use of bone marrow and adipose-derived cells for cartilage regeneration. They discuss the technique for obtaining bone marrow and highlight the importance of proper technique to maximize the number of cells obtained. They also mention the use of bone marrow concentration systems to increase cell numbers. The speaker recognizes that there is currently poor evidence for the effectiveness of bone marrow aspirate concentrate (BMAC) in treating arthritis, but suggests that more research is needed to understand the different formulations and their effects. They present data on the use of BMAC for cartilage defects, which shows promising results. In terms of adipose-derived cells, the speaker discusses the technique for obtaining fat tissue, including abdominal liposuction and arthroscopic harvest. They present evidence from trials suggesting that adipose-derived cells can decrease pain and increase function in osteoarthritis patients, with some evidence of cartilage thickening. The speaker also discusses the use of juvenile chondrocytes and highlights the need for further research in this area. They caution against the use of allogeneic tissue, such as amniotic fluid and amniotic tissue, due to limited understanding of its biological effects and potential complications. The speaker briefly mentions the remodeling of subchondral bone as a potential technique to address abnormal bone and cysts. They present early evidence suggesting positive outcomes in bone remodeling. The speaker concludes by emphasizing the need for further research and caution in the field of cartilage regeneration.

Asset Caption

Dr. Jason L. Dragoo

Keywords

regenerative medicine

cellular therapy

cartilage regeneration

BMAC

osteoarthritis

research