Orthopaedic Use of Biologics in 2025 (AANA25)-Hype, Promise, and Reality: Orthopaedic Use of Biologics in 2025

Video Transcription

Video Summary

The video transcript involves a detailed seminar focusing on orthopedic biology, specifically biologics in orthopedics, for rotator cuff repair. It begins with Scott Rodeo discussing cell therapy, rotator cuff repair, and the complex biology involved in healing, highlighting matrix synthesis, cell migration, and inflammatory mediators. He also emphasizes a responsible and evidence-based approach in using biologics, cautioning against aggressive marketing and hasty application of unapproved therapies.<br /><br />Significant portions address the use of different cell sources such as bone marrow and adipose tissue. Rodeo brings attention to the fact that healing with cell therapy can be unpredictable due to numerous unknowns about cell populations and the complexity of chronic inflammatory processes in conditions like tendinopathy.<br /><br />Ken Zasloff follows, expanding on the subject by focusing on Platelet-Rich Plasma (PRP) injections for osteoarthritis, explaining their biochemical efficacy, reviewing clinical studies, and discussing challenges related to PRP effectiveness, including issues related to PRP composition, specific growth factors, and the importance of a patient-tailored approach.<br /><br />The seminar concludes with discussions about technological advancements in cartilage restoration strategies presented by Jason Drago, mentioning the potential of umbilical cord cells and other regenerative methodologies, and exploring the practicality and ethical considerations of these advanced treatments.<br /><br />The video underscores the complexities and ethical challenges practitioners face with orthobiological treatments, as well as the promising future of personalized medicine in orthopedics. Attendees are urged to keep a rigorous, knowledge-based approach to ensure patient safety and treatment efficacy.

Asset Caption

Stephen C. Weber, M.D. | Kenneth R. Zaslav, M.D. | Scott A. Rodeo, M.D. | Jason L. Dragoo, M.D., FAANA

Keywords

orthopedic biology

biologics

rotator cuff repair

cell therapy

matrix synthesis

inflammatory mediators

bone marrow

adipose tissue

Platelet-Rich Plasma

osteoarthritis

cartilage restoration

umbilical cord cells

personalized medicine